Drugs.com clearly lists "Wrinkled Skin" as a potential side-effect from Opana ER; I have, and continue to have this issue, especially on the inner sides of my elbows and on my neck. The wrinkles are unlike typical age related wrinkles, with these going in the wrong direction, and appearing raised, and having a crisscross appearance. However, the manufacturer, other on-line med sites, and my Doctor, dismisses these wrinkles as not having anything to do with the Opana ER! I would be highly interested if other Opana ER users have experienced this, or perhaps have not noticed them, and/or did not associate them with the medication? I applaud Drugs.com for their in depth research!