I've been taking nycenta 50mg at night as needed. And nycenta ER if I get pain during the day as needed. I try not to take it often and only as needed. I have fibromyalgia and myesthinia gravis. Spinal fusion with instrumentation c3 to c7. It works great but I noticed my memory is awful and I'm very depressed. Not normally like that. Could it be comming from the nycenta? I don't think I take it often enough for that kind of reaction. Less than once a week