I had an adverse reaction to Avandia gaining over 60# of excess fluid which included a 15 # gain in less than a week after my dossage was doubled from 4 mg to 8mg. I eneded up in the ER with chest pains. Heart Cath turned up normal, was taken off avandia and put on medformin and januvia. Within months I was diagnosed with Fatty Liver Disease. I went from 240# to 308# while on Avandia and Actos. Is there a link to Avandia and Organ Damage ? This Drug has ruined my life!