I've been on Nexium for 4 months and was prescribed it because I was prescribed Arcoxia. Have always had acid reflux and it's definitely helped with that and I don't get any effects from the Arcoxia. I went off both for a week and then back on both again and noticed weight gain in the wk, also stinging pain on my stomach and Pain in throat & chest plus burping. Have read it affects bone density. Thanks in advance for any answer! ☺