I have mixed connective tissue disease. Doctor said it was mild and wants me to do plaqenil 200 mg twice daily. Does anyone know what the side effects of this drug are. And also how do you manage the side effects? The doctor said that it can damage my retina but the medication is also given to pregnant women. What are all my options for medications and what are the side effects of any possible medications? And had anyone had mixed connective diease for a while and what is it like in the long run? Also does autoimmune disorders cause anxiety? I feel nervous a lot and nothing stressful is really going on. Thanks