I started on Vibryd about a year ago--20mg a day. I had tried lots of other stuff with and without alcohol, which was a major source of the underlying depression (I quit after rehab about a year ago). Weight gain has been a huge issue. I was only holding things at bay with vigorous exercise, which I had to stop because of very severe joint pain. Hips, ankles, knees--ouch. I have gained 25 pounds. When my Dad died in February I went home and drank beer with my brother for three weeks and lost 20 pounds. I stopped the Vibryd that whole time. I came home, got sober again, started Vibryd again, and gained all the weight back and more! I have always been healthy and athletic and now I am a fat, sore, old broad. I am so done with this drug.