I have had GAD with panic for over 20 years. Went on Lexapro and it worked great for almost a decade. It pooped out, tried Zoloft (just made me mad and irritated) then went to Prozac and Valium. It seemed to work "OK" for about 2 years and pooped out also. My doctor had me try Lexapro again, but ad of now (two weeks in), the only thing holding me together is the Valium at the moment, but still suffering from constant anxiety.
My question is, since I have tried such an array of SSRI's and most of the popular ones at that, where do I go from here? I'm going to see my pdoc in a day or.so, but would like to have some options to talk to her about Thank you for any input you can give
Added 16 Jan 2017:
Also, I have never really suffered from depression....I do get sad when these attacks flare up, but I'm normally a very happy, outgoing person
Celexa and Paxil are the two SSRI's you haven't mentioned yet. On the SNRI side, you would be looking at Effexor or Cymbalta. those are the antidepressants that remain that can be used to treat anxiety. Outside of that you would be looking at benzodiazepines which would include Valium Xanax etc. and then there's also a medication called BuSpar which is something that either works fantastically great for people or doesn't work at all. The nice thing about it is that it does not have addictive properties so you can try it and if it does work for you, it's better to take that then it is to take a benzodiazepine. I see what you're getting at in terms of switching to an SNRI if the SSRIs have been ineffective - basically, it would stimulate your body to produce norepinephrine and serotonin wall right now you're taking a medication that only stimulates serotonin. It's not a bad idea to try, but if I could give you my own personal advice, I would try the Effexor before Cymbalta. Cymbalta is known for associated weight gain, and when you try to get off of it, it is very common for people to have a tremendous amount of difficulty stopping the medication. In the SSRI category, the same thing can be said for Paxil, and so ultimately you need to be very careful with whatever decision you make as your potentially dealing with addiction on the benzodiazepine side or you're dealing with potential weight gain and tolerance with some of the antidepressants. You might do well to give your current treatment a little more time and make sure that it's not working before you decide to make the switch because when you do make that switch you're making a commitment that could be long-term not just a short term quick try of something new. I hope this information helps a little bit. :-)
Stay away from SNRI medications, folks! The people who have developed this type of drug have no regard for what it actually does to the patient! It has taken me one year to get off of Cymbalta! It actually increased my depression. I am on my second day of Effexor. Yesterday the words 'I feel great' rolled off of my tongue before I realized what I had said.
However, keep this in mind:
Venlafaxine (Effexor, Effexor XR) has the flexibility of being an SSRI at lower doses (75 mg/day), affecting the reuptake of serotonin, and an SNRI at higher doses (150-225 mg/day). It also very weakly blocks the reuptake of dopamine at very high doses (above 350 mg/day).
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