As far as I know, they did the same thing to Opana ER that they did to OxyContin. They made it more abuse resistant. They have added a polymer to make it very difficult to split or crush. If you were to hit one with a hammer it wont crush into powder but flattens out and may break into large pieces. When you try to mix these pieces with liquid, say water, to inject, it turns into a gloppy, gummy mixture that is impossible to draw up in a syringe and inject. If they try to snort the powder, same thing, it goops up in the nose and wont absorb properly. If you take the pill by swallowing whole, however, you shouldnt be able to tell much difference between the new formula and the old. Now with OxyContin, they changed one more thing. They changed the rate that it absorbs into the bloodstream.
The old formula of OxyContin immediately released 40-60% of the total dose in a bolus then trickled the remaining drug in over the next 12 hours so the old OxyContin formula was really both immediate release and extended release. The new OxyContin formula is now totally time release. It doesnt give the immediate release bolus anymore so many people feel it doesnt work as well since it takes much longer to begin to work after swallowing it. I am not sure if Opana ER was changed in this way or not. I have not been able to find that part out. But they did add the polymer to prevent an abuser from being able to inject or snort the drug. It should still be very effective for severe pain!
I would agree with the first poster if I hadn't read on this sight about other problems with the O.P's. Some people had them pass right through & into the toilet. Now I don't know how many people that's happened to so overall maybe they work fine,but there were some other posts about different problems & friday someone was saying the same thing about Opana,it might have just been what z said so who knows. People who abuse those are always trying some way to beat the tamper resistant additives. I read where people are putting them in the oven I guess to try and "dry" out the polymer?
- Opana Information for Consumers
- Opana Information for Healthcare Professionals (includes dosage details)
- Side Effects of Opana (detailed)
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