I have a very severe form of RLS and have used ReQuip, rotigotine patches (NeuPro), Horizant, gabapentin, etc. We're now trying amantadine... I can't say that it's working, but would love some suggestions or feedback from other sufferers. I'm going to try CBD oil very soon on the recommendation of my physical therapist. The RLS is really affecting the quality of my life and I am anxious to get some real relief .