... pinpoint. It started small on Sunday and I took a Naproxen. The original hives went away but overnight Sunday it became horrible. Went to doc Monday and got a Benadryl and Prednisone shot and am now taking these orally. The swelling and hives get worse as it moves around. If there is a chance that it is the (one) Naproxen causing this should I not be taking the Prednisone? Could that actually be making it worse?