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If name brand dexedrine is a better drug than Adderall, then what dose is best?

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duckworthy 10 Feb 2013

Dear Wavespell,

There really isn't one right answer to this question... Dexedrine is the brand name for a time-released formulation of dextroamphetamine sulfate - available in 5-, 10-, and 15-mg doses. Dextroamphetamine sulfate is also one of the four amphetamine-based compounds that make up Adderall (the other three being dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate). FYI - Adderall tablets are available in 5-, 7.5-, 10-, 12.5-, 15-, 20-, and 30mg tablets of this combination; Adderall XR capsules (time-released) are available in 5-, 10-, 15-, 20-, 25-, and 30mg doses.

The efficacy of one drug over the other - as with any other pharmaceutical under the sun - varies from patient to patient. I'm not sure who the source was that advised you Dexedrine is "a better drug" than Adderall - what they meant is nebulous at best (in my opinion). It's likely true that some patients have had a better, overall, clinical experience with Dexedrine - and with fewer side effects - than they did with Adderall; but the flipside (Adderall vs. Dexedrine) is likely true as well. The same can be said when comparing any other medications that are prescribed to treat similar conditions (say, like Crestor vs Lipitor, for treating high cholesterol, as an example).

By the same approach, there isn't really a single answer when it comes to what dose of Dexedrine or Adderall is best, either. The general approach a prescribing physician would likely follow is to begin the patient on the lowest dose of whichever drug is better tolerated, and then gradually increase that dose and/or its frequency as needed until the optimal effect is achieved (again, with minimal side-effects).

I'm sorry this isn't really the cut-and-dry answer you were likely hoping to find. Your best bet would be to take the matter up with your physician, in order to get the best answer for you - and you alone.

Best of luck to you in your endeavors.


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