... part of my back near my shoulder. I have been on the Mylan patch now for the last five years but lately I have been going through withdrawal with the patch it tends not to release the medication like it should I am now trying it on my upper arm and I am going through the worst withdrawal ever. Any suggestions and if I do try a new location how long does it take for it to last I want to try it on my thigh where people keep saying is the best location but how long will it take for the medication to start to work?