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How is Mydayis different to Adderall XR?

Answers (1)

Official Answer by 10 Oct 2017

Mydayis (amphetamine and dextroamphetamine) from Shire was FDA-approved in June 2017. Mydayis is a long-acting, once daily stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 13 years and older. Mydayis contains similar active ingredients as Adderall XR but is formulated to last up to 16 hours. Adderall XR only lasts up to 12 hours, and is given once daily. The ages of use differ also: The Adderall XR capsule can be used in patients 6 years of age and older, while Mydayis is used in patients 13 years and older. Adderall XR can be purchased in a cost-saving generic formulation, but Mydayis is not available generically.

Mydayis has a triple-bead release formulation for long action. It contains equal amounts (by weight) of four salts: dextroamphetamine sulfate and amphetamine sulfate, dextroamphetamine saccharate and amphetamine aspartate monohydrate. This results in a 3:1 mixture of dextro-to levo-amphetamine base equivalent.

Adderall XR combines the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextro isomer of amphetamine saccharate and d,l-amphetamine aspartate monohydrate. While Mydayis has a triple-bead release action, the Adderall XR capsule contains two types of drug-containing beads designed to give a double-pulsed delivery of amphetamines. This action prolongs the release of amphetamine from Adderall XR compared to the conventional Adderall (immediate-release) tablet formulation.

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