... sulfasalazine daily (starting with 1,000 and gradually increasing). His doctor said he should take this amount for 1 year. He is having some adverse effects as in insomnia, sore throat, but worse of all depression and irritabililty. Here is my question. His doctor said that it takes up to 3 months for the sulfasalazine to work. If this is true, will these symptoms go away? He wants to stop the medication now and I can't say I blame him. It's been a horrible last 3 months (from diagnoses, to now). As the doctor doesn't take the medication, what is your advice?