... diphenhydramine..He will sleep 11-13 hrs then gets up an lays on the sofa,falls asleep for maybe 2 more hours.He also takes 100mg Zoloft.He has been layed off from his job 2 months an he worked the 4pm-4am shift for several years .When he got layed off he said he needed something to help him get back into a routine of night time sleeping.Its been 2 months now and I am very worried that this may interact with his meds an that he is staying so drained an tired because of the otc sleep aid.Please reply an answer my question.Thank you