... getting the weight off either while still on tysabri or after you stopped treatment? I've gained 20 pounds since I started my treatments 5 months ago. I workout daily and my diet hasn't changed. I'm just as my wits end with the the weight gain. I realize I should be happy that his drug is keeping my flareups away but I have been experiencing a wide variety of symptoms that this drug can have. The weight gain is just really getting to me.