My mother is 73 years old with well controlled DM & HT. Metastatic CA breast disease progression has markedly slowed down with Afinitor since 9 monthes. However, this diarrhea is disabeling & caused 15 Kg weight loss. We have tried Smecta (Diosmectite) , kapect (Kaolin-Pectin) ,emodium(Loperamide), Lacteol fort (Lactobacillus),Rifaximin 200mg alone and in various combinations. None worked. Please advice. Thank you