I was on Cipramil for over 15 years when it stopped working. Took me nearly a year to recognise that I had fallen back into depression. Doctor put me on 100gm Pristiq. Did not work until the 3rd week. Still not quite there yet as I still have days where I just want to sleep all day. Have gained weight and since on it and my sex life still has not returned. Hopefully both will improve as time goes by.