... I'm a paranoid freak about mixing medications. The info that came with the Opana ER is really scary (specifically the breathing stuff, where u can ultimately die or go into coma). I'm currently also taking Norco 5/325 for bt pain, and Amitriptyline 25mg at night. All 3 can cause depressed breathing I believe. Anybody else taking mixes like this? My pharmacist seemed to think it was pretty standard for people in chronic pain