I have missed a dosage occasionally. After all, it is not a pleasant drug. How many days elapsed before you realized you missed it? What is your dosage?
When I miss a dosage (e.g., I want to enjoy a social event) I return to the schedule ASAP. If I miss more than a few days I wait until the next weekly dose. My experience has been that if I miss more than two weeks, I start to feel my stiffness increase quite rapidly, no matter what the dosage.
I used to take 9x3 mg tablets per week from 1977, then lesser doses since then in combination with newer TNFs. When my "bloods" went bad, I would stop for four to six weeks depending on subsequent blood tests. My arthritis worsened quite rapidly.
- Methotrexate Information for Consumers
- Methotrexate Information for Healthcare Professionals (includes dosage details)
- Side Effects of Methotrexate (detailed)
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