I was prescribed Metformin a couple of weeks ago. As an initial dose I was give 500mg (250 twice daily) side effects minimal at this time. A few days ago my dosage was increased to 500 mg twice daily. Now the side effects are crazy... upset stomach, diarrhea, urinary retention and a few minor side effects. I asked my pharmacist and she said all this was normal and that my body had to adjust. The other night I was up all evening and half the night in the washroom. Don't think I can get used to that. Any help would be appreciated.