I know this answer is very, very late but may help someone in future.
There are no known interactions between metaxalone and Flexeril, so they can be taken together (if your doctor has prescribed it to be used together). And yes, one can be taken in the morning and the other one at night.
- Metaxalone Information for Consumers
- Metaxalone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Metaxalone (detailed)
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