... virtually disappeared, I've cut it back to 1 in AM & PM. When I told my doctor/PA (new one), she said she would check, but wanted directions to reflect what I was actually taking. She sent new RX for 4 - 375mg daily. When questioned, she said to take AS DIRECTED! My 400mg said 2-twice a day. After reading your information, I think 2-twice a day is correct, but she was clear about 4-at a time??? No way to start with new PA.