... both arms in the area from wrists to elbows. I transitioned in October 2015 from weekly injections to monthly infusions of ORENCIA and the number of blood spots have increased, does any other RA patient taking or not taking ORENCIA, have blood spots? Are these dangerous, what causes them? I am due for my 2nd infusion and visit with my rheumatologist next week, 11/12/15, I would appreciate any feedback if anyone is experiencing blood spots, wanting to know if caused by RA or the medication (ORENCIA).