There are few, if any, antidepressants that do not have the potential to cause weight gain because of their effect on the human metabolism although some are more weight neutral than others. On average, only about 10 - 12% of antidepressant users report weight gain and that gain is clinically insignificant. Interestingly, almost an equal number of users report decreased appetite and weight loss and an average of 7 - 8% of users receiving a placebo in controlled clinical studies also reported weight gain.
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