Are there any medications that raise dopamine without raising norepinephrine?
Medications that raise dopamine only?
- Asked
- 30 Sep 2015 by Sphynxx
- Updated
- 3 October 2015
- Topics
- depression, anxiety, dopamine, norepinephrine, anxiety and stress, antidepressant, medication
Responses (2)
This not an answer. I'm sure I have read that some of the Parkinsons disease medications have that mode of action. I had good results with a serotonin antagonist leaving natural dopamine levels, presumably, the same.
I believe you would be looking in the area of ADD, ADHD meds.
I take Adderall, but it raises both dopamine and norepinephrine. I'd like to be able to take only dopamine because too much norepinephrine makes me feel very sick.
I take Adderall, but it raises both dopamine and norepinephrine. I'd like to be able to take only dopamine because too much norepinephrine makes me feel very sick.
There are a ton of research chemicals, but when it comes to straight dopamine drugs, they're not typically prescribed because of their reward centers and people 'wanting' more. There is one that starts with a D and ends in opine that is used as a stimulant, and it must be able to be prescribed to humans, as it has been used to treat symptoms of Parkinson's Disease. If it's still being prescribed, it's definitely a controlled substance, because it has a chemical structure related to you know - the white powder people ruin their lives over.
It would be equivalent to doing coke, crack, or meth! Addiction and nonhabitual, uncontrollable, even criminal behaviours. I'll stick with approved antidepressants and not try to screw around with my brain's chemicals and functions, thank you!! There's a reason they're not used.
Just out of curiosity, how have you been able to establish that the neurochemical norepinephrine 'makes you sick'? Do you mean nauseous? And if so, how did you come to the conclusion that it was the N?

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I know exactly the one you're talking about, and you're correct - it's called Mirapex
Could Mirapex be effective for treating depression?
Hmm... no, I don't know about that one. I was prescribed it for restless leg syndrome. It has an unfortunate side effect of potentially causing people to do things unlike themselves. I came to realize that I was waking up in the middle of the night, getting online with my computer, and placing orders worth hundreds - without quite realizing what I was doing. Things arrived at my door and I had no idea what they were, or why they had come for me. I came to realize that I was exhibiting the behavior I had been warned about, and it was showing itself in the form of excessive spending, during hours when I was only semi-conscious. I had to discontinue the drug immediately.
If it were effective for depression wouldn't doctors prescribe it for depression?