... try for depression will almost always conflict with the Luvox because its a SSRI. I am just scared to come off Luvox because it saved me when I had a break down from both my OCD symptoms and panic disorder but I have been on it for 7 years so its worth giving another drug a try like anafrinl I am just nervous. FYI- I am coming off Wellbutrin which I incessited on because I have been on it for yrs. for depression and it has done nothing at for depression. I will see my new psych. and ask him to taper me off Luvox and go on Anfranil and then maybe I try something like pristiq for my depression