Can you dumb it down for me quite a bit please? As I've said recently I just changed from Kadian 50mgEr x2 day to OpanaER 15mg x 2 day and have been reading more about it and it's "new" formulary. I really felt like I was taking a step up, but darn if I only want to get 10% of the effects of my meds. My dosing instructions say take on an empty stomach but I also read that you could eat a small but fatty diet or drink some grapefruit juice with your Opana to (uninhibit/block?IDK?)to the CYP450 inhibitor to get better than 10% bioavailability, so I would assume better pain relief, yes or no? Does anyone understand this and are you able to help me understand! I've only had 3 doses of the Opana So far but I am feeling worse than I was on the Kadian and that was certainly NOT the objective. I do realize that my body is going to need some time to adjust but I'm hurting and very jumpy/anxious NOT FUN!! :,(
In a nutt shell, when taken orally, 10% of the drug gets actively used by your body, the rest is not used. 15 mg of Opana taken orally means that about 1.5 mg will become active in your body.
In your situation, I would recommend that you discuss your observation with your perscribing physician. Do not try to alter the route of administration or otherwise change the expected bioavalability of Opana as this can result in serious overdose and other unwanted sideffects including death and onset of withdrawal symptoms.
If you are not getting sufficient pain relief seek a pain management specialist who you can work with and who will adequatly address your pain.
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