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What major interactions would be connected to a vivitrol shot?

Responses (1)

chuck1957 21 Dec 2014

Mottamade,,, Sorry i copied and paste both pills and injection but the info is the same for both Im not really sure what you mean by interaction supprise this is one of the few things to get you off of opiates and you don't have alot of side effects like say people coming off alcohol with antabuse... Opiates just don't really give relief and even small amounts of alcohol.i would not reccommend it you could have some problems..I hope this well help you please feel free to contact me or many here are good at answering these type of questions so moore or less it just makes opiates of anytype pretty much feel less than nothing please read this copy and paste and see if it answers your question..if not be very specific and let me know and i well see if we can focus in on what your having problems with..a friend chuck1957 it does say can make you feel kind of flu like feeling taking these together but it has worked very well for people with trouble with opiates..Chuck 1957 Mechanism of Action
Naltrexone is an opioid antagonist with highest affinity for the mu opioid receptor. Naltrexone has few, if any, intrinsic actions besides its opioid blocking properties. However, it does produce some pupillary constriction, by an unknown mechanism.

The administration of Vivitrol is not associated with the development of tolerance or dependence. In subjects physically dependent on opioids, Vivitrol will precipitate withdrawal symptomatology.

Occupation of opioid receptors by naltrexone may block the effects of endogenous opioid peptides. The neurobiological mechanisms responsible for the reduction in alcohol consumption observed in alcohol-dependent patients treated with naltrexone are not entirely understood. However, involvement of the endogenous opioid system is suggested by preclinical data.

Naltrexone blocks the effects of opioids by competitive binding at opioid receptors. This makes the blockade produced potentially surmountable, but overcoming full naltrexone blockade by administration of opioids may result in non-opioid receptor-mediated symptoms such as histamine release.

Vivitrol is not aversive therapy and does not cause a disulfiram-like reaction either as a result of opiate use or ethanol ingestion.

Pharmacokinetics

Absorption
Vivitrol is an extended-release, microsphere formulation of naltrexone designed to be administered by intramuscular (IM) gluteal injection every 4 weeks or once a month. After IM injection, the naltrexone plasma concentration time profile is characterized by a transient initial peak, which occurs approximately 2 hours after injection, followed by a second peak observed approximately 2 - 3 days later. Beginning approximately 14 days after dosing, concentrations slowly decline, with measurable levels for greater than 1 month.

Maximum plasma concentration (Cmax) and area under the curve (AUC) for naltrexone and 6β-naltrexol (the major metabolite) following Vivitrol administration are dose proportional. Compared to daily oral dosing with naltrexone 50 mg over 28 days, total naltrexone exposure is 3 to 4-fold higher following administration of a single dose of Vivitrol 380 mg. Steady state is reached at the end of the dosing interval following the first injection. There is minimal accumulation (<15%) of naltrexone or 6β-naltrexol upon repeat administration of Vivitrol.

Distribution
In vitro data demonstrate that naltrexone plasma protein binding is low (21%).

Metabolism
Naltrexone is extensively metabolized in humans. Production of the primary metabolite, 6β-naltrexol, is mediated by dihydrodiol dehydrogenase, a cytosolic family of enzymes. The cytochrome P450 system is not involved in naltrexone metabolism. Two other minor metabolites are 2-hydroxy-3-methoxy-6β-naltrexol and 2-hydroxy-3-methoxy-naltrexone. Naltrexone and its metabolites are also conjugated to form glucuronide products.

Significantly less 6β-naltrexol is generated following IM administration of Vivitrol compared to administration of oral naltrexone due to a reduction in first-pass hepatic metabolism.

Elimination
Elimination of naltrexone and its metabolites occurs primarily via urine, with minimal excretion of unchanged naltrexone.

The elimination half life of naltrexone following Vivitrol administration is 5 to 10 days and is dependent on the erosion of the polymer. The elimination half life of 6β-naltrexol following Vivitrol administration is 5 to 10 days.

Special Populations
Hepatic Impairment: The pharmacokinetics of Vivitrol are not altered in subjects with mild to moderate hepatic impairment (Groups A and B of the Child-Pugh classification). Dose adjustment is not required in subjects with mild or moderate hepatic impairment. Vivitrol pharmacokinetics were not evaluated in subjects with severe hepatic impairment (see PRECAUTIONS).

Renal Impairment: A population pharmacokinetic analysis indicated mild renal insufficiency (creatinine clearance of 50-80 mL/min) had little or no influence on Vivitrol pharmacokinetics and that no dosage adjustment is necessary (see PRECAUTIONS). Vivitrol pharmacokinetics have not been evaluated in subjects with moderate and severe renal insufficiency (see PRECAUTIONS).

Gender: In a study in healthy subjects (n=18 females and 18 males), gender did not influence the pharmacokinetics of Vivitrol.

Age: The pharmacokinetics of Vivitrol have not been evaluated in the geriatric population.

Race: The effect of race on the pharmacokinetics of Vivitrol has not been studied.

Pediatrics: The pharmacokinetics of Vivitrol have not been evaluated in a pediatric population.

Drug-Drug Interactions
Clinical drug interaction studies with Vivitrol have not been performed.@@@@@@@@@@@@ THIS would have been what you asked... chuck.

Naltrexone antagonizes the effects of opioid-containing medicines, such as cough and cold remedies, antidiarrheal preparations and opioid analgesics (see PRECAUTIONS).

chuck1957 21 Dec 2014

Mott ps you might want to look at one of the support groups and see what others are saying with simular problems... More power to you... it well work out and you well feel so much better in time..Chuck1957

Mottamade 21 Dec 2014

Thanks chuck I am alcohol dependant and receive vivitrol however not sure y

chuck1957 21 Dec 2014

oKAY SORRY i kept saying opiates its kind of a 50/50 but this here does not hurt your liver and stuff anything like antabuse,,So good luck and no alohol lol if i can help just let me now i hope i did not confuse you to much..Remember if you have a different problem opimium won't do you much good so make sure you tell any doctor your on this medication... best wishes..stay strong Chuck1957

Mottamade 21 Dec 2014

Thanks again chuck

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