Short answer: YES! (lamictal + Lexapro, but same idea). Lamictal basically saved my life.
Long answer: I had untreated cycling major depression and anxiety since childhood (am now late forties). Got much worse in recent years which got me to finally get treatment--it wasn't that I was stubborn, it was just that when its allyou kno, you asume that there is no other way to be... ) Anyway, SSRI plus bupropion plus klonopin helped maybe 50%--barely worth the side effects. Tried a high dose bupropion, and got my first taste of mania--what a trip! Almost left my partner of 25 years (to whom I was always faithful) and my kids to take up with a kind and gentle 30 year old. Then my good Dr. put me on Lamictal, titrated over 3 month to 300 mg/day. 50 mg--no effect, 100 mg--maybe a little better; 200 mg--noticeable improvement but still bouts of despair every week or so; 300 mg--a miracle! The cycling faded and now is uncommon and very mild. Still need the klonopin for anxiety, but may try to wean from bupropion soon. So, patience!
I am on a cocktail of 100mg lamotrigine, 400 mg of wellbutrin (preauth required), plus prozac, started at 20 mg (transitioned from 40 mg Celexa) and just increased to 40 mg prozac. Celexa worked very well for me other than horrific weight gain, which triggered the switch to Prozac. 20mg prozac still had me in tears half the time so really hoping the new dose will help. I don't want to go back to Celexa, but if this doesn't work, I'll have to.
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