In short, nothing but an attached group of molecules which very subtly effect strength, duration, and addictive potential, and one has APAP in it while the other does not. The math is pretty much like this: Vicodin (hydrocodone) is 2 times less potent in pain management at is oxycodone, vicodin rarely, even after long term use causes life threatening withdrawal where as oxycodone will likely do so. Finally, hydrocodon lasts about an hour to two longer than oxycodon.
Side note: The likelihood of a deadly overdose of the medications is backwards because of the APAP in Vicodin. In other words, you are more likely to die from taking too many of the weaker hydrocodon/APAP mixture than from greater quanity of the more potent oxycodone alone. The reason is all about the APAP... it causes liver failure and a slow rotting effect when overdosed on and should in all honesty not be approve for over the counter use. The FDA would never approve it today.
2 7.5/325 Vicodin should be equivilant in pain releif as would be 1 and a half 5mg oxycodone. Just remember not to mix oxycodon up with Oxycontin or you'll be in a sh*t load of trouble. 10mg Oxycontin is like 18 hours of about 20 mg oxycodon. Seeing as it's simply a time release version of oxycodon, I'm unsure as to why this is, but the data is conclusive.
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