Built up a high tolerance for many of the meds especially ones to treat depression & anxiety. I may be considered med resistant. Due to this I fear that even on a high dose of Lyrica it will quickly lose its positive effects in helping with overall Blah & Pain from Fibro & Lupus. Has anyone had Lyrica work for awhile then fade out? I started on 75mgs twice a day & I felt good for 4 days & then it effects fizzled out. Doc just increased my dose to 150mgs twice a day which I just started tonight. Thank you.