Hello. I have been on Seroquel XR for almost two years now. For most of that I was on 150 mg, then went up to 200 mg and then 300 mg because of depression. Recently, I tried to get off the medicine and went down to only 50 mg. At that dose, I had more energy than I've had in years, but had to increase it to 100 mg for various reasons. Now I am more tired than ever.

I am completely knocked out less than two hours after taking my dose, and when I wake up after getting a lot of sleep I'm still exhausted. My question is, do lower doses make you more tired? I'm so confused, because I was on 150 mg for so long and in terms of tiredness, I was doing fine. And even on 200 and 300 mg, I felt less tired than I do now.

Thank you for helping with this.