Lorcet, Vicodin and Norco (among a few others) are what is known as "combination analgesics". This is because they contain more than one medication. When you see a strength of a drug written with a slash between them, it means there are two drugs. In this case, the first number, 10, refers to 10mg of hydrocodone, the opioid (or narcotic) component of the drug. The second number refers to the amount of acetaminophen (otherwise known as Tylenol). Adding this acetaminophen boosts the pain relieving properties of either drug on its own. So the difference, in your question, refers to a difference of 300mg of acetaminophen.
- Lorcet 10 / 650 Information for Healthcare Professionals (includes dosage details)
- Side Effects of Lorcet 10 / 650 (detailed)
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