Hi, I was prescribed Zoloft (Sertraline) 25mg 5 weeks ago for OCD and anxiety. I was on 25mg for the first 3 weeks and noticed no difference so my doctor increased the dosage to 50mg. I have been on 50mg for the last two weeks and still feel no difference in mood, or anxiety level. Is this normal? If so, how long til the 50mg kicks in? Do I need a higher dosage?