Hi, I was prescribed Zoloft (Sertraline) 25mg 5 weeks ago for OCD and anxiety. I was on 25mg for the first 3 weeks and noticed no difference so my doctor increased the dosage to 50mg. I have been on 50mg for the last two weeks and still feel no difference in mood, or anxiety level. Is this normal? If so, how long til the 50mg kicks in? Do I need a higher dosage?
It's understandable that you didn't feel anything at the 25, but there should be much more hope at 50. Two weeks in may not lift you out of your depression, but there should be little signs of improvement, like energy and appetite. If nothing has improved at all, it's time to give your doc a call. The worst that would happen is they want you try it for two more weeks. Likely they'll want you to try a medicine with a slightly different mechanism.
Sertraline is an SSRI, and works by increasing seratonins in the brain. It usually takes about 4-6 weeks before you feel any changes.
Based on my experience, you can feel something sooner. It just depends on your own body chemistry.
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