What are the long term effects of taking DIPHENHYDRAMINE (or Unisom sleepgels) every day over several years?
There aren't any serious side effects from taking diphenhydramine once daily for a long time. Why are you taking it? If for allergy it is probably ok however if you are taking it for a sleep problem there are more effective short term products available. Speak to your doctor if you are concerned.
https://www.drugs.com/sfx/diphenhydramine-side-effects.html for a comprehensive list of side-effects.
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