I'm 35 and my ob/gyn recommended that I try Estrace since I was experiencing burning and irritation after having sex. All my labs came back normal for infections and I'm using lubrication as well. My question is, I used 1 gram on Sunday night and it is now Tuesday and the cream is still inside me. I'm afraid to have sex with my boyfriend because it may show on his penis (embarrassing for me and I haven't told him I'm trying this cream out). Does anyone know how long it stays inside? I thought it was suppose to leak out eventually. I was told to use it 1-2 days a week. Any answers would be appreciated :).