I've been on Cymbalta for nearly 3 weeks now for major depression, and haven't really noticed any change at all. I know they say it could take 4-6 weeks for maximum effectiveness, but I'm unclear what that means? Does this mean I won't see changes at all until 4-6 weeks, or should I be noticing gradual changes sooner than that? I've been really bad for 4 straight months and I'm just desperate to feel better.