. I tried a couple of weeks ago and my HR went Sky Hi like in the the 90's at rest and up to 105.My heart Dr wants me to switch to Diltiazem ER because I have COPD and use Advair.and albuterol which you aren't suppose to take together... timolol is a Beta blocker and a really old med closing up my veins and that's not good!! Been taking it for 30 years.