Whats the time frame for taking this medication before it could start to cause damage to the liver? And how whould one know if any liver damage has begun? I hand knee surgery in Feb.of 2012 and was told I have Rhematiod Arthritis as well... Febuary is when i first started the pain medicine Hydro/Acetami and have continued to current time Oct. 2012 (10 mons). Sometimes I take 2 at a time within 6 hour period because the pain is so bad in my hands arms and feet. Could there be damage in my liver already? I have noticed I'm sleeping much less now then ever before and I'm having to use the bathroom 2 to 3 times during the night almost every nite for the last 2 to 3 months. I'm so dang scared of using any drug for longer than a year. Thank you so much!!