I take 150 mg sertraline in the morning,3 mg of prazosin for ptsd nightmares at night,along with 150 mg of trazadone,enough to relax me to fall asleep. I see a phsyc dr. once every 3 mos. to check meds,and one more counseling apt,( I was going once a month). My view is,I am feeling the best I have ever felt! If things are working,why change? It tokk me awhile to get everything adjusted right,I have been on these meds and dosages for about 6 mos. Does anyone know of any long term affects? I want things to stay as they are,thanx ahead of time for any input you might share with me! Happy and staying that way! P.S.,prazosin is a miracle for ptsd nightmares!!