Yes; from the product information here at Drugs.com:
"Patients with Hepatic Impairment.
Opana is contraindicated in patients with moderate or severe hepatic impairment. Use Opana with caution in patients with mild hepatic impairment, starting with the lowest dose (e.g., 5 mg) and titrating slowly while carefully monitoring side effects [see Warnings and Precautions (5.6) and Clinical Pharmacology (12.3)]."
- Opana Information for Consumers
- Opana Information for Healthcare Professionals (includes dosage details)
- Side Effects of Opana (detailed)
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