I have been on every antidepressant imaginable, and I have finally had progress with Remeron (Mirtazapine ). However, I gained a lot of weight, mostly fluid retention, so I was given Lasix in the ER and have had it prescribed for 3 months. Lost 9 lbs in 24 hours, but still can't get into regular shoes. Anyway, my gp did not put refills on the Lasix and my pdoc switched me to Spironolactone,. I have been on it for 2 days and the horrific leg swelling has returned. Is it true that this med on its own is useless? Since it's the weekend, I can't get a hold of the doctor's office, even though I left a detailed description to the answering service. I don't want to go back to ER, as my daughter's birthday party is tomorrow and I have a house full of kids spending the night. Bad timing! Anyone know whether 25mg of the Spironolactone is just too low, or is it true that it only works when coupled with Lasix (furosemide)? And will Lisinopril act as a diuretic as well?