I also have trouble with anger. Ihave had trouble for many years or major depressive disorder and it seems to be getting worse as I get older. How long does it take to go off lexapro. I am on 10 mg. after going down from 20 and have had a tantrum and crying all day. I have to add that i have tried many different meds, paxil, imipramine, effexor, cymbalta and 1 or 2 others. Imipramine worked the best but the side effects were bad in mnay ways. I also have panic disorder and find myself isolating more and more. But I want to know people's opinions on lexapro and i really want to get off this stuff.