I've been taking psychiatric medications for years and I am very compliant, although I will occasionally forget a dose for one day only (I never skip two days in a row.) Now I just started Latuda about four months ago and I am up to 80mg once/day at bedtime. I have never noticed a difference after skipping a day of my other drugs, but now suddenly when I skip Latuda I always have a really bad day the next day. Is this some sort of placebo effect that I'm imagining or does Latuda actually have a short enough half life that a significant amount of it is out of my system after 24 hours?