Has anyone tried this combo for depression? if so, what was your experience? efficacy? side effects? Thanks
Morning BH; first the way you said your question your not taking Lamictal and also Lamotrigine RIGHT they are the same thing but one is the brand and one is the generic name. So you should just be taking the 2 different things. I did check for any Interactions between the two and there are none. Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
But anyway this is a pretty common combinations being used and many have done very well on these 2 medications. Just be aware that when you first start the Brintellix for the first few weeks you get some side effects but those do go away after the first 10 to 14 days for most and at that point you do start to feel a little better this is all normal Most complain about headache, nausea, dizzy, feeling of sedation all are very common but these are the ones that go away. But if any are just to much you can check with your doctor and see what you can do to lesson them. Anytime after that period we start to notice some feeling better but it can take as much as 6 to 8 weeks when your blood level is reached and you should get the best benefits of the medication. So try and have some patients and know you should be feeling better but it might take a little time..Hope it works out for you Chuck1957
This combination works GREAT for me. I have been on lamotrigine 300 mg/day for over 10 years (split into A.M. and P.M.), and Brintellix 2.5 mg/day (P.M. only) for over one year. I have bipolar + OCD.
I have realistic expectations. No med I've ever tried has worked perfectly, and no med I've ever tried has no side effects. However, these two work the best and have the least side effects of any I've tried.
Other meds I tried and failed with before lamotrigine/Brintellix:
- Prozac, Lexapro, Paxil (extreme brain fog, sleepiness, weight gain)
- Wellbutrin (amped up,irritated, angry)
- Abilify (crazy, rapid cycling)
- Acamprosate (didn't do anything)
Lamotrigine keeps me stable -- cuts the extreme highs and extreme lows of bipolar. I don't know what I'd do without this med. I think I've lost some cognitive function, but for me the benefit has far outweighed that downside. Except for some initial side effects when first ramping up on lamotrigine (headache I think), the reduced cognitive function is the only one that's remained. However, this whole time I've successfully worked in a highly technical field, so the cognitive hit must not be that bad.
Although Lamotrigine kept me stable, I needed something else to further reduce the lows to make life tolerable. Given my failure with the meds listed above, my psychiatrist suggested Brintellix. I was skeptical but gave it a try anyway.
I am still very surprised -- it must have been just what I needed, because it really did help pull me up that last bit I needed. I added the Brintellix over a year ago and am still feeling good on it. The main side effect for me was nausea. That actually took me several months to beat, but because the Brintellix worked so well, I hung in there. Basically, I had to take it within a very, very small window of time (directly after a big dinner) to keep the nausea at bay. I experimented with the timing over many months, and finally that window of time widened so the nausea is rarely a problem anymore. I just have to remember to take it after dinner and at least an hour before I go to bed, but those are the only restrictions, so it is easy to manage. However, even if I forget to take it until just before bedtime, I only get slight nausea, nothing too bad like the beginning.
I started at 5 mg and because it worked so well, went up to 10 mg to see if that was even better. However, I didn't notice any increase in effectiveness at that dose, and I got an additional side effect, weight gain. So I lowered it back down to 5 mg, and that was fine, and then thought what the heck and lowered it down to 2.5 mg, which is an extremely small dose, and that works just as well for me, with no weight gain. I am 5'1 and 108 pounds.
Everyone's needs are different, so I can't say how this combo or what dose would work for anyone else, but I wanted to share my experience.
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