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How does Kyleena compare to Liletta, Mirena and Skyla?

Answers (1)

Official Answer by Drugs.com 30 Nov 2016

Kyleena (levonorgestrel intrauterine system) 19.5 mg is a low-dose progestin intrauterine device (IUD) indicated to prevent pregnancy for up to 5 years.

The main difference between IUDs are the groups of women they can be used in, the length of effectiveness, and the total amount of hormone per device. Kyleena is the first IUD that lasts for 5 years that can be used in women regardless of whether they have had children or not. Liletta and Skyla, effective for 3 years, can also be used in women regardless of whether they have given birth or not.

Mirena lasts for 5 years, like Kyleena, but is only approved to be used in women who have already given birth to at least one child.

Other differences exist in the total amount of hormone per device, which may alter menstrual flow. Skyla and Kyleena have lower levels of progestin, 13.5 mg and 19.5 mg of levonorgestrel, respectively, while Liletta and Mirena both have 52 mg of levonorgestrel.

The IUDs with higher levels of progestin will result in lighter - or even absent - periods, and may be beneficial in women who have problems with heavy bleeding.

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