I have Primary Sjogren's - my symptoms are severe, though not debilitating. Within hours of my first dose, I noticed my body began to ache (an overall ache no one area in particular). I didn't think anything of it until my second dose when the pain got worse. I feel it in my bones, my joints are cracking when I move, and when I try to walk or extend my fingers it feels like the tendons are pulling. I had been previously diagnosed with salivary stones and inflammation - which had been causing a sporadic tingling sensation along my jawline. Since starting the Evoxac the random tingling has expanded to my cheek with occasional twitching at the left corner of my mouth. Will this subside with time? Does my body just need an adjustment period?