I've been taking lasix successfully for a long time. Along with the lasix, I took cialis every other... day. Recently I had to start taking several new drugs. Now the lasix doesn't seem to be working very well.. I've checked the drug interactions but don't see anything to tell me if any of the new drugs would interfere with the way lasix has worked in the past. The new drugs are digoxin, metolazone, carvedilol, diltiaz, coumedin. Does anyone know if there is a problem between these drugs and lasix that doesn't show up on the drug interactions? Could it be the timing of the pills? Should they be taken later than the lasix? The dr told me to take the metolazone 1 hour before the lasix. Thanks for your help