... Does anyone know the difference? Is the Oxycontin more effective on pain then the Hydrocodone. It seems that going from 325 mg of Hydrocod to only 10mg of Oxycontin that I am going to be left in killer pain. I forgot to ask and of course it's friday after 5pm... any help appreciated but only if you are knowledgable about the 2 drugs. I'm in liver failure so I just want to know I won't be suffering. Thank you kindly : )